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What is mescaline exactly, where does it come from, and what affects does it have on a user?

Known to chemists as 3,4,5-trimethoxyphenethylamine, mescaline is an alkaloid that is commonly found in peyotes but can also be found in other cacti including San Pedro and Peruvian torch. Laboratory-synthesised mescaline is also available for use in research.

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The following explains why your tour guide would have advised against eating any random local cacti in case you found yourself in a survival crisis while in the desert: You need your brains to survive, so it’s not ideal to trip over barriers or poison yourself in the blazing heat while thirsty.

In any case, if you are not stranded in Death Valley, what will mescaline do to you? What are the potential risks and benefits of the psychedelic plant?

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DOSAGE AND CONSUMPTION

Peyote has been used in spiritual ceremonies by Native Americans for thousands of years. To develop mescaline, the buttons of the cactus, which grow on top of the roots, are harvested. After drying, the buttons can be pulverized to make mescaline capsules or brewed into a tea.

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The typical initial dosage is 10–20 grams of dried peyote buttons with a maximum mescaline content of 100 mg. After consumption, mescaline takes one to three hours to begin acting, and its effects last for a further ten to twelve hours. Of course, the dose determines the trip’s duration and intensity.